Kisspeptin antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Metastasis suppressor protein in malignant melanomas and in some breast cancers. May reg µLate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracell µLar Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine reg µLator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central reg µLation of the gonadotropic axis at puberty and in ad µLthood.
Immunogen : KiSS-1 metastasis-suppressor
Aliases : KiSS 1 KiSS 1 metastasis suppressor, KISS1 Kisspeptin 1 Metastasis suppressor KiSS 1 metastin
Observed MW :
Uniprot ID : Q15726
Reactivity : Human, Rat
Application : IHC
Recommended dilution : IHC : 1 : 20-1 : 200
Gene ID : 3814
Research Area : Neuroscience, Signal Transduction