LIN7A antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated m µLtiprotein complexes that may reg µLate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7(LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B(subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter(SLC6A12) and EGFR/ERBB1 ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
Immunogen : lin-7 homolog A(C. elegans)
Aliases : MALS1 VELI1
Observed MW : 28-30 kDa
Uniprot ID : O14910
Reactivity : Human, Mouse, Rat
Application : ELISA, WB, IP, IHC
Recommended dilution : WB : 1 : 500-1 : 2000; IP : 1 : 200-1 : 1000; IHC : 1 : 20-1 : 200
Gene ID : 8825
Research Area : Neuroscience