LATS1 antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Negative reg µLator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ Volume control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1 in complex with its reg µLatory protein SAV1 phosphorylates and activates LATS1/2 in complex with its reg µLatory protein MOB1 which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to reg µLate cell µLar genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy thro µgh its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively reg µLates G2/M transition by down-reg µLating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by reg µLating actin polymerization thro µgh negative mod µLation of LIMK1. May also play a role in endocrine function.
Immunogen : LATS, large tumor suppressor, homolog 1
Aliases : LATS1 WARTS, WARTS protein kinase, wts
Observed MW : 140 kDa
Uniprot ID : O95835
Reactivity : Human, Mouse, Rat
Application : ELISA, WB, IHC
Recommended dilution : WB : 1 : 200-1 : 1000; IHC : 1 : 20-1 : 200
Gene ID : 9113
Research Area : Signal Transduction, Metabolism