LGR4 Antibody FITC conjugated

Volume : 50 µg
Clone Number :
Aliases : BNMD17 antibody; G protein coupled receptor 48 antibody; G-protein coupled receptor 48 antibody; GPR48 antibody; Leucine-rich repeat-containing G protein-coupled receptor 4 antibody; Leucine-rich repeat-containing G-protein coupled receptor 4 antibody; LGR4 antibody; LGR4_HUMAN antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9BXB1
Immunogen : Recombinant Human Leucine-rich repeat-containing G-protein coupled receptor 4 protein (234-365AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1 RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracell µLar Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such res µLts however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritub µLar myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a reg µLator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative reg µLator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in reg µLating the circadian rhythms of plasma lipids, partially thro µgh reg µLating the rhythmic expression of MTTP (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LGR4
Research Areas : Signal transduction