LAPTM4B Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : LAPTM4B antibody; PSEC0001 antibody; Lysosomal-associated transmembrane protein 4B antibody; Lysosome-associated transmembrane protein 4-beta antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q86VI4
Immunogen : Recombinant Human Lysosomal-associated transmembrane protein 4B protein (174-226AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Required for optimal lysosomal function (PubMed : 21224396). Blocks EGF-stim µLated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, reg µLates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed : 25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stim µLating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed : 25998567). Plays a role as negative reg µLator of TGFB1 production in reg µLatory T cells (PubMed : 26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed : 26280656).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LAPTM4B
Research Areas : Cancer