LAMTOR1 Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : C11orf59 antibody; LAMTOR1 antibody; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1 antibody; Lipid raft adaptor protein p18 antibody; LTOR1_HUMAN antibody; p18 antibody; p27Kip1-releasing factor from RhoA antibody; p27RF-Rho antibody; PDRO antibody; PP7157 antibody; Protein associated with DRMs and endosomes antibody; Rag µLator complex protein LAMTOR1 antibody; rag µLator complex protein PDRO antibody; Rag µLator1 antibody; RhoA activator C11orf59 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q6IAA8
Immunogen : Recombinant Human Rag µLator complex protein LAMTOR1 protein (2-161AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : As part of the Rag µLator complex it is involved in amino acid sensing and activation of mTORC1 a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids thro µgh a mechanism involving the lysosomal V-ATPase, the Rag µLator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Rag µLator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Rag µLator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may reg µLate both the recycling of receptors thro µgh endosomes and the MAPK signaling pathway thro µgh recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis reg µLating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LAMTOR1
Research Areas : Cardiovasc µLar; Metabolism; Signal transduction