LIN28B Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : CSDD 2 antibody; CSDD2 antibody; FLJ16517 antibody; Lin 28 homolog B (C. elegans) antibody; Lin 28.2 antibody; Lin-28B antibody; LIN28B antibody; LN28B_HUMAN antibody; Protein lin-28 homolog B antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q6ZN17
Immunogen : Recombinant Human Protein lin-28 homolog B protein (166-250AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1 and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed : 22118463). Does not act on pri-miR21 (PubMed : 22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed : 19703396). This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent (PubMed : 22118463). Interaction with target pre-miRNAs occurs via an 5\'-GGAG-3\' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression (By similarity). When overexpressed, isoform 1 stim µLates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LIN28B
Research Areas : Epigenetics and Nuclear Signaling; Cancer