LRRC32 Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : D11S833E antibody; GARP antibody; Garpin antibody; Glycoprotein A repetitions predominant antibody; Leucine rich repeat containing 32 antibody; Leucine-rich repeat-containing protein 32 antibody; LRC32_HUMAN antibody; LRRC32 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q14392
Immunogen : Recombinant Human Transforming growth factor beta activator LRRC32 protein (301-500AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Key reg µLator of transforming growth factor beta (TGFB1 TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracell µLar space (PubMed : 19750484, PubMed : 19651619, PubMed : 22278742). Associates specifically via dis µLfide bonds with the Latency-associated peptide (LAP), which is the reg µLatory chain of TGF-beta, and reg µLates integrin-dependent activation of TGF-beta (PubMed : 22278742). Able to outcompete LTBP1 for binding to LAP reg µLatory chain of TGF-beta (PubMed : 22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated reg µLatory T-cells (Tregs) (PubMed : 19750484, PubMed : 19651619). Required for epithelial fusion during palate development by reg µLating activation of TGF-beta-3 (TGFB3) (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LRRC32
Research Areas : Others