LMP2 Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : LMP2 antibody; Latent membrane protein 2 antibody; Terminal protein antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Epstein-Barr virus (strain B95-8) (HHV-4) (Homo sapiens (Human) herpesvirus 4)
UniProt ID : P13285
Immunogen : Recombinant Epstein-Barr virus Latent membrane protein 2 protein (1-147AA)
Raised in : Rabbit
Species Reactivity : Epstein-Barr virus
Tested Applications : ELISA
Background : Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglob µLin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molec µLar scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglob µLin-negative cells to colonize peripheral lymphoid organs.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LMP2
Research Areas : Others