LAIR1 Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : 5133400O11Rik antibody; CD305 antibody; D7Bwg0421e antibody; hLAIR1 antibody; LAIR 1 antibody; LAIR-1 antibody; LAIR1 antibody; LAIR1 protein antibody; LAIR1_HUMAN antibody; Leukocyte associated Ig like receptor 1 antibody; Leukocyte associated immunoglob µLin like receptor 1 antibody; Leukocyte-associated immunoglob µLin-like receptor 1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q6GTX8
Immunogen : Recombinant Human Leukocyte-associated immunoglob µLin-like receptor 1 protein (22-165AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Functions as an inhibitory receptor that plays a constitutive negative reg µLatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation res µLts in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracell µLar calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Mod µLates cytokine production in CD4+ T-cells, down-reg µLating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-reg µLates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LAIR1
Research Areas : Immunology