Calpastatin(CAST/1550) , CF647 conjugate , 0.1mg / mL

Calpastatin is an inhibitor of calpain (calcium-activated intracellular cysteine protease). Calpastatin regulates calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types , tissue type and erythrocyte type , resulting from both alternative splicing and proteolytic processing. Calpastatin co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization , such as the acrosome reaction. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.